Relapse pattern and prognostic factors for patients with primary CNS lymphoma

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Relapse pattern and prognostic factors for patients with primary CNS lymphoma

Age Median (Range) 59 (28-76) 53 (33-65) 0.260 Age 0.253 ≥60 20 (47.6%) 5 (27.8%) <60 22 (52.4%) 13 (72.2%) Gender 0.241 Male 25 (59.5%) 14 (77.8%) Female 17 (40.5%) 4 (22.2%) Involvement sites 1.000 Intracranial lesion only 38 (90.5%) 15 (83.3%) Extracranial involvement 6 3 Leptomeningeal seeding 4 2 Ocular lesion 1 1 Spinal cord 1 0 B Symptom 1.000 Yes 1 (2.4%) 0 (0.0%) No 41 (97.6%) 18 (100....

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Relapse pattern and prognostic factors for patients with primary central nervous system lymphoma

BACKGROUND Primary central nervous system lymphoma (PCNSL) rarely relapses in extracranial sites, and no specialized guidelines for follow-up evaluation have been proposed. METHODS We analyzed 65 patients with newly diagnosed PNCSL to evaluate the pattern of relapse and prognostic factors. RESULTS Of the 65 patients analyzed, 55 had only parenchymal brain disease, and 10 had both intracrani...

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V. Primary CNS lymphoma in immunocompetent patients

Primary CNS lymphoma (PCNSL) is an aggressive brain tumour, representing 3% of intracranial neoplasms and 4%–6% of extranodal lymphomas with a yearly incidence of 0.5 cases per 100 000 people and with a median survival, if untreated, of 1.5–3.3 months. The incidence of PCNSL in the past two decades has risen in immunocompetent individuals, especially in those >50 years of age. Median age at dia...

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Prognostic impact of BCL-6 in primary CNS lymphoma

BACKGROUND We investigated the prognostic significance of B-cell differentiation status and common B-cell differentiation markers in a post hoc analysis of 119 patients with primary CNS lymphoma (PCNSL) homogeneously receiving high-dose methotrexate (HDMTX)-based chemotherapy within the prospective G-PCNSL-SG1 trial. METHODS We evaluated protein expression of B-cell lymphoma 2 (BCL2), BCL6, CD1...

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Posttransplant primary CNS lymphoma.

The records and neuro-imaging studies of 8 cases of posttransplant primary CNS lymphoma (PT-PCNSL) diagnosed at Mayo Clinic Rochester between 1970 and 1998 were reviewed retrospectively. All patients received organ transplantation. Patients who had hematologic transplantation were not included in the analysis. The median and mean age of the 4 men and 4 women was 45 years (range, 34 to 50 years)...

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ژورنال

عنوان ژورنال: The Korean Journal of Hematology

سال: 2012

ISSN: 1738-7949,2092-9129

DOI: 10.5045/kjh.2012.47.2.155